Pardon the impending pun — or actually, don’t, because it doesn’t deserve your mercy — but one of three things is afoot here.
2010 Comic-Con - EW And CBS Celebrate Comic-Con Fandemonium

1) Kaley Cuoco is wearing shoes that look like Ace bandages strapped to a shoe mold;

2) Kaley Cuoco actually NEEDS to wear Ace bandages for some injury reason or other, and so is trying to make the best of it;

3) Kaley Cuoco has mummified her lower extremities.
If it’s either one or three, subdue her with liquor and then strap her to a table in Barneys until she comes back to her senses.

Edited to add: Apparently it’s two! Props to her, then, for trying to have fun.